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AICAR (5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside, 5-aminoimidazole-4-carboxamide ribonucleoside, acadesine) is each of several interesting things. First, it’s an important pharmacological research agent, used principally as an AMPK activator. It’s a compound which has shown extremely impressive fat-loss and endurance-enhancing effects in laboratory animals. Further, it has considerable mystique resulting from at least some use by elite European cyclists. And lastly, it’s readily available from research chemical sites and is being personally tried by many, though generally as part of stacks and combined with changes in training and/or diet.
Pause, however, may be given when considering that treatment programs for cyclists reportedly have cost in the tens to hundreds of thousands of Euros, that all reported studies in the scientific literature have used dosing which indeed would be extraordinarily costly when scaled up for human dosing, and that the experience base of bodybuilding usage at far lower doses is equivocal at best.
